Choosing the right solvent for preparative liquid chromatography

• Author(s): Ribeiro, António E. ; Graça, Nuno S. ; Gomes, P. Sá ; Pais, L.S. ; Rodrigues, A.E.
• Date: 2012
• Persistent ID: http://hdl.handle.net/10198/9143
• Origin: Biblioteca Digital do IPB
• Subject(s): Mobile phase composition; Preparative chromatography; Simulated moving-bed
• Document Type: Conference Object
• Language: English

Description

In this work we pretend to clear demonstrate that the choice of the proper solvent is crucial for both analytical and preparative separations. The work developed in the last years by the LSRE group will be described with three real optimization case-studies: two non-steroidal anti-inflammatory drugs (the separation of ketoprofen and flurbiprofeno enantiomers) and one antihypertensive drug (the separation of nadolol stereoisomers).