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Choosing the right solvent for preparative liquid chromatography
Ribeiro, António E.; Graça, Nuno S.; Gomes, P. Sá; Pais, L.S.; Rodrigues, A.E.In this work we pretend to clear demonstrate that the choice of the proper solvent is crucial for both analytical and preparative separations. The work developed in the last years by the LSRE group will be described with three real optimization case-studies: two non-steroidal anti-inflammatory drugs (the separation of ketoprofen and flurbiprofeno enantiomers) and one antihypertensive drug (the separation of nad...
Influence of solvent composition on chiral separation of flurbiprofen and ketop...
Ribeiro, António E.; Gomes, P. Sá; Pais, L.S.; Rodrigues, A.E.Nowadays, simulated moving bed (SMB) chromatography is a well-established technique for chiral separation, as confirmed by the actual large number of published works in chemical and pharmaceutical research. Although there is a considerable number of published works on SMB technology, there are still few concerning the influence of mobile phase composition in SMB operation. This is a new topic on SMB research wi...
Separation of nadolol stereoisomers by liquid chromatography : screening of the...
Ribeiro, António E.; Gomes, P. Sá; Pais, L.S.; Rodrigues, A.E.The screening of the most convenient mobile phase composition is presented for the chiral separation of the four stereoisomers of the beta-blocker drug nadolol. When the final goal is the preparative chiral separation, this selection is critical, since solubility, selectivity and retention are all parameters very sensitive with mobile phase composition. Experimental results will show that the best mobile phase ...
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