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Multicomponent chiral separations by multicolumn and simulated moving bed adsor...
Ribeiro, António E.; Graça, Nuno S.; Ferreira, Alexandre P.; Rodrigues, A.E.; Pais, L.S.This work will present a complete methodology concerning experimental, modelling and simulation results. Both the CHIRALPAK AD and CHIRALPAK IA CSP will be evaluated. The selection of the proper CSP/solvent combination for preparative operation will be fully study taking into account the screening strategy proposed by Zhang et al. Additional results include the measurement of nadolol stereoisomers solubilities,...
Multicomponent chiral separations by analytical and preparative liquid chromato...
Ribeiro, António E.; Pais, L.S.; Rodrigues, A.E.This work will present a complete methodology concerning experimental, modelling and simulation results. Both the CHIRALPAK AD and CHIRALPAK IA CSP will be evaluated. The selection of the proper CSP/solvent combination for preparative operation will be fully study taking into account the screening strategy proposed by Zhang et al. Additional results include the measurement of nadolol stereoisomers solubilities,...
Choosing the right solvent for preparative liquid chromatography
Ribeiro, António E.; Graça, Nuno S.; Gomes, P. Sá; Pais, L.S.; Rodrigues, A.E.In this work we pretend to clear demonstrate that the choice of the proper solvent is crucial for both analytical and preparative separations. The work developed in the last years by the LSRE group will be described with three real optimization case-studies: two non-steroidal anti-inflammatory drugs (the separation of ketoprofen and flurbiprofeno enantiomers) and one antihypertensive drug (the separation of nad...
Chiral separation of nadolol stereoisomers by liquid chromatography : screening...
Ribeiro, António E.; Pais, L.S.; Rodrigues, A.E.This work describes a systematic approach to rapid development of simulated moving bed (SMB) chiral chromatographic separations. The presented methodology involves several pulse experiments using a single-column to screen the best mobile phase composition using a Chiralpak AD stationary phase and equilibrium adsorption data used to specify the initial flow rates of the SMB operation.
Optimization of simulated moving bed processes for multicomponent chiral separa...
Ribeiro, António E.; Rodrigues, A.E.; Pais, L.S.This work will present and discuss the experimental and simulation results obtained for the analytical and preparative separation of the four stereoisomers of nadolol, an important example of a non-selective beta-adrenergic receptor antagonist (beta-blocker) pharmaceutical drug, widely used in the treatment of cardiovascular system diseases, such as hypertension, ischemic heart disease (angina pectoris), conges...
Methodologies for the separation of chiral drugs by liquid chromatography: from...
Ribeiro, António E.; Rodrigues, A.E.; Pais, L.S.The main goal of the present work is to clear demonstrate that the selection of the proper solvent composition is a key step for both analytical and preparative separations. A complete methodology developed in the last years inside the LSRE group will be described. Three real optimization case-studies will be presented: two non-steroidal anti-inflammatory drugs (the separation of ketoprofen and flurbiprofen ena...
Chemical composition of different oregano (origanum vulgare l.) essential oils:...
Amaral, J.S.; Ribeiro, António E.; Alves, Sofia; Gonçalves, Alexandre; Poeta, PatríciaHerbs and spices have been used for centuries in culinary for seasoning and flavouring purposes. More recently, there has been a growing interest regarding the use of some plants and its essential oils (EO) for their activity against foodborne pathogens and foodspoilage bacteria. Due to its potential in extending the self-life of foods and its better acceptability by consumers who demand more “natural” foods, t...
Influence of solvent composition on chiral separation of flurbiprofen and ketop...
Ribeiro, António E.; Gomes, P. Sá; Pais, L.S.; Rodrigues, A.E.Nowadays, simulated moving bed (SMB) chromatography is a well-established technique for chiral separation, as confirmed by the actual large number of published works in chemical and pharmaceutical research. Although there is a considerable number of published works on SMB technology, there are still few concerning the influence of mobile phase composition in SMB operation. This is a new topic on SMB research wi...
Chiral separation of non-steroidal anti-inflammatory drugs by preparative and s...
Ribeiro, António E.; Gomes, Pedro Sá; Pais, L.S.; Rodrigues, A.E.The work presents modelling, simulation and experimental results for the chiral separation of non-steroidal anti-inflammatory drugs, particularly, the optimization of mobile phase composition under preparative and simulated moving bed chromatography. The experimental separation of two chiral systems (ketoprofen and flurbiprofen enantiomers) will be presented to show how compounds of the same family can lead to ...
Separation of nadolol stereoisomers by liquid chromatography : screening of the...
Ribeiro, António E.; Gomes, P. Sá; Pais, L.S.; Rodrigues, A.E.The screening of the most convenient mobile phase composition is presented for the chiral separation of the four stereoisomers of the beta-blocker drug nadolol. When the final goal is the preparative chiral separation, this selection is critical, since solubility, selectivity and retention are all parameters very sensitive with mobile phase composition. Experimental results will show that the best mobile phase ...
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