Synthesis and evaluation of the antitumor potential of new aminated or methoxyl...

• Autor(es): Calhelha, Ricardo C. ; Campos, Joana F. ; Peixoto, Daniela ; Abreu, Rui M.V. ; Ferreira, Isabel C.F.R. ; Queiroz, Maria João R.P.
• Data: 2013
• Identificador Persistente: http://hdl.handle.net/10198/8684
• Origem: Biblioteca Digital do IPB
• Tipo de Documento: Documento de conferência
• Idioma: Inglês

Descrição

Synthesis and evaluation of the antitumor potential of new aminated or methoxylated di(hetero)arylthioethers in the thieno[3,2-b]pyridine séries. In 1st Symposium on Medicinal Chemistry. Braga Several thienopyridines have already been described as inhibitors of cell proliferation using human tumor cells[1,2], highlighting the interest of studying their antitumorpotential. ln this work, we present the synthesis of di(hetero)arylthioethers 1a-fby SNAr of the 7-chloro thieno[3,2- b]pyridine with amino or methoxy thiophenols in good to high yields, like presented in the scheme.