Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2...

• Author(s): Queiroz, Maria João R.P. ; Peixoto, Daniela ; Soares, Pedro ; Abreu, Rui M.V. ; Froufe, Hugo J.C. ; Calhelha, Ricardo C. ; Ferreira, Isabel C.F.R. ; Costa, Raquel ; Soares, Raquel
• Date: 2012
• Persistent ID: http://hdl.handle.net/10198/7357
• Origin: Biblioteca Digital do IPB
• Document Type: Conference Object
• Language: English

Description

A number of thienopyrimidines derivatives have shown potent YEGFR2 (Vascular Endothelium Growth Factor Receptor2) inhibition activity [ 1]. YEGF is a surrogate marker of angiogenesis that activates VEGFR2 in endothelial cells. VEGF induces proliferation, migration and anastomosis of these cells. Here we present the synthesis of new l-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas, by reaction of 4-aminophenol with 4-chlorothieno[3,2-d]pyrimidine giving compound 1, which was reacted with arylisocyanates to give the corresponding I ,3-diarylureas 2a-c (Scheme).