Synthesis of aminodiarylamines in the thieno[3,2-b]pyridine series and effects ...

• Author(s): Calhelha, Ricardo C. ; Ferreira, Isabel C.F.R. ; Abreu, Rui M.V. ; Vale-Silva, Luís A. ; Pinto, Eugénia ; Lima, Raquel T. ; Alvelos, M. Inês ; Vasconcelos, M. Helena ; Queiroz, Maria João R.P.
• Date: 2011
• Persistent ID: http://hdl.handle.net/10198/6241
• Origin: Biblioteca Digital do IPB
• Document Type: Conference Object
• Language: English

Description

Several series of compounds that include the thienopyridine scaffold have been reported as inhibitors of known cancer therapeutic targets or as inhibitors of cell proliferation in tumor cell lines [1,2]. Our research group has already synthesized several thieno[3,2-b]pyridine derivatives by Pd-catalyzed C-C (Suzuki and Sonogashira) and C-N (Buchwald-Hartwig) couplings and some of them have presented tumor cell growth inhibitory activity in cell lines [3- 5].