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Chemical study and biological activity evaluation of two Azorean Macroalgae: Ul...
Silva, Madalena; Vieira, Luís M.; Almeida, Ana Paula; Silva, Artur M. S.; Seca, Ana M. L.; Barreto, Maria do Carmo; Neto, Ana I.; Pedro, MadalenaCopyright: © 2013 Silva M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credite. ; The green macroalga Ulva rigida C. Agardh (Chlorophyta) and the red macroalga Gelidium microdon Kützing (Rhodophyta), collected from the Azore...
Formação docente e cidadania : políticas dinâmicas e processos de formação docente
Pinto, Eugénia Maria de Morais PereiraDissertação de mestrado em Ciências da Educação (área de especialização em Educação de Adultos) ; Este trabalho centra-se no estudo da formação contínua de professores, tendo como principais objetivos: a) contribuir para a compreensão da problemática da formação para a cidadania à luz do paradigma da educação de adultos e aprendizagem ao longo da vida, b) clarificar a pertinência da formação enquanto conceito ...
New potential antitumoral di(hetero)arylether derivatives in the thieno[3,2-b]p...
Queiroz, Maria João R. P.; Dias, Sofia; Peixoto, Daniela; Rodrigues, Ana Rita O.; Oliveira, Andreia D. S.; Coutinho, Paulo J. G.; Silva, Luís A. ValeNew fluorescent methoxylated di(hetero)arylethers in the thieno[3,2-b]pyridine series were prepared by a copper-catalyzed Ullmann-type C-O coupling of the methyl 3-amino-6-bromothieno[3,2-b]pyridine-2-carboxylate with ortho, meta and para-methoxyphenols, using N,N-dimethylglycine as the ligand and Cs2CO3 as the base. The compounds obtained were tested for their inhibitory growth activity in three human tumor c...
Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series : synthesis, effe...
Callhelha, Ricardo C.; Ferreira, Isabel C. F. R.; Peixoto, Daniela; Abreu, Rui M. V.; Silva, L. A. Vale; Pinto, Eugénia; Lima, Raquel T.Three aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N Buchwald-Hartwig coupling of methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with different bromonitrobenzenes, followed by reduction of the nitro groups of the coupling products to the corresponding amino compounds. The aminodi(hetero)arylamines thus obtained were evaluated for their growth inhibitory effect on four human tumor cell ...
Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, effec...
Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Peixoto, Daniela; Abreu, Rui M.V.; Vale-Silva, Luís A.; Pinto, Eugénia; Lima, Raquel T.; Alvelos, M. InêsThree aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N Buchwald-Hartwig coupling of methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with different bromonitrobenzenes, followed by reduction of the nitro groups of the coupling products to the corresponding amino compounds. The aminodi(hetero)arylamines thus obtained were evaluated for their growth inhibitory effect on four human tumor cell ...
Unverricht–lundborg disease: report of a new mutation
Freitas, Joel; Pinto, Eugénia; Duarte, A.J.; Amaral, Olga; Chaves, Joao; Lopes-Lima, J.AJD e DR: bolseiros FCT. ; P301: Unverricht-Lundborg disease is the most frequent cause of progressive myoclonic epilepsy. CSTB mutations, with cystatin B loss of function, have been described as the major cause of this disease.
Nanoliposomes for encapsulation and delivery of the potential antitumoral methy...
Abreu, Ana S.; Castanheira, Elisabete M. S.; Queiroz, Maria João R. P.; Ferreira, Paula M. T.; Silva, Luís A. Vale; Pinto, EugéniaA potential antitumoral fluorescent indole derivative, methyl 6-methoxy-3-(4-methoxyphenyl)-1H-indole-2-carboxylate, was evaluated for the in vitro cell growth inhibition on three human tumor cell lines, MCF-7 (breast adenocarcinoma), A375-C5 (melanoma), and NCI-H460 (non-small cell lung cancer), after a continuous exposure of 48 h, exhibiting very low GI50 values for all the cell lines tested (0.25 to 0.33 µM)...
Synthesis and evaluation of tumor cell growth inhibition of Methyl 3-Amino-6-[(...
Queiroz, Maria João R. P.; Calhelha, Ricardo C.; Silva, Luís A. Vale; Pinto, Eugénia; Almeida, Gabriela M.; Vasconcelos, M. HelenaThe methyl 3-amino-6-bromothieno[3,2-b]pyridine-2-carboxylate, recently reported by some of us, was reacted in Sonogashira couplings with several (hetero)arylacetylenes. The growth inhibitory activity of the novel methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates obtained was evaluated on three human tumor cell lines (MCF-7, NCI-H460, A375-C5). The para-methoxyphenyl and the ortho and p...
Synthesis of aminodiarylamines in the thieno[3,2-b]pyridine series and effects ...
Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Abreu, Rui M.V.; Vale-Silva, Luís A.; Pinto, Eugénia; Lima, Raquel T.; Alvelos, M. InêsSeveral series of compounds that include the thienopyridine scaffold have been reported as inhibitors of known cancer therapeutic targets or as inhibitors of cell proliferation in tumor cell lines [1,2]. Our research group has already synthesized several thieno[3,2-b]pyridine derivatives by Pd-catalyzed C-C (Suzuki and Sonogashira) and C-N (Buchwald-Hartwig) couplings and some of them have presented tumor cell ...
Estudo molecular da epilepsia mioclonica progressiva Unverricht-Lundborg
Pinto, Eugénia MariaAs Epilepsias Mioclónicas Progressivas (EMP) estão associadas a um grupo heterogéneo de doenças metabólicas raras. São caracterizadas clinicamente por mioclonias, crises tónico-clónicas e declínio neurológico progressivo com ataxia e demência. A doença de Unverricht-Lundborg (DUL), epilepsia mioclónica progressiva tipo 1 (EPM1, MIM 254800) e principal causa de EMP, é uma doença autossómica recessiva causada por...
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