Tumor de células de Leydig do ovário: caso clínico

• Author(s): Saleiro, S ; Gonçalves, S ; Marinho, C ; Rebelo, T ; Manarte, A ; Oliveira, CF
• Date: 2009
• Persistent ID: http://hdl.handle.net/10400.4/728
• Origin: Repositório do Centro Hospitalar e Universitário de Coimbra
• Subject(s): Neoplasias do Ovário; Tumor de Células de Leydig
• Document Type: Article
• Language: Portuguese

Description

Leydig cell tumours account for 0.1% of all ovarian tumours and are a type of steroid cell tumour. According to the World Health Organisation they are classified in the group of sex cord stromal tumours. The clinical presentation is usually a hyperandrogenic state with signs of virilisation, but occasionally patients may exhibit a hyperestrogenic state. The tumour has a benign behaviour, with an excellent prognosis and reversion of symptoms after treatment. The authors present the case of a 61 year-old woman with signs of virilisation that started 8 months before. Abdomino-pelvic computerized tomography showed an enlarged left ovary, while blood hormone analisys revealed increased levels of testosterone, androstenedione and 17-OH progesterone. The patient was submitted to laparoscopic bilateral oophorectomy. Histological examination revealed a Leydig cell tumour of the left ovary. After surgery there was complete regression of symptoms and normalisation of sex hormone levels.