The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 ...

• Author(s): Lemos, MC ; Coutinho, E ; Gomes, L ; Bastos, M ; Fagulha, A ; Barros, L ; Carrilho, F ; Geraldes, E ; Regateiro, FJ ; Carvalheiro, M
• Date: 2009
• Persistent ID: http://hdl.handle.net/10400.4/656
• Origin: Repositório do Centro Hospitalar e Universitário de Coimbra
• Subject(s): Diabetes Mellitus Tipo 1; Antigénio CD; Predisposição Genética para Doença
• Document Type: Article
• Language: English

Description

CTLA4 genetic polymorphisms have been associated with type 1 diabetes. We genotyped 207 patients and 249 controls for the most frequently investigated polymorphism of the CTLA4 gene (+49A/G (rs231775)). No significant differences were observed, suggesting that this polymorphism is not strongly associated with type 1 diabetes in the Portuguese population.