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Deflazacort: a possible alternative in corticosteroid allergy

Hipercortisolismo Recorrente: Após Remoção de Adenoma Hipofisário Secretor de A...

A 29 years old patient was sent to our Outpatient Clinic of Endocrinology presenting clinic of hypercortisolism. Laboratorial study: High urinary free cortisol (UFC); serum cortisol - 25 microg/dl (8 am) (5-25) and 20 microg/dL (11pm); ACTH - 20 pg/mL (9-52) (8 am) and 14 pg/mL (11 pm); serum cortisol after dexamethasone suppression test: 14,9 mg/dL; CRH test: elevation of ACTH; Pituitary MRI: microadenoma; abd...

The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 ...

CTLA4 genetic polymorphisms have been associated with type 1 diabetes. We genotyped 207 patients and 249 controls for the most frequently investigated polymorphism of the CTLA4 gene (+49A/G (rs231775)). No significant differences were observed, suggesting that this polymorphism is not strongly associated with type 1 diabetes in the Portuguese population.

Lack of association of vitamin D receptor gene polymorphisms with susceptibilit...

The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms and the genetic susceptibility to type 1 diabetes in the Portuguese population. We genotyped 207...

Carcinoma anaplásico da tiróide: análise retrospectiva de 12 casos

Anaplastic thyroid tumor is a rare tumor and constitutes 5 to 10% of thyroid carcinomas. Is one of the most aggressive solid tumors and the prognosis is always fatal with a mean survival of 3 to 7 months. The current therapeutics are scarce and inefficacious. A retrospective analysis was performed in 12 clinical cases of anaplastic thyroid tumor observed at the Department of Endocrinology, Diabetes and Metaboli...

Tiroidites agudas

We review the pathophysiology, clinical features and therapy of acute thyroiditis. Four cases are reported stressing the role of fine needle aspiration for the diagnosis of this clinical entity.

Local immunosuppression in clinical small bowel transplantation (report of two ...

Lung tissue mechanics in the early stages of induced paracoccidioidomycosis in ...

Pulmonary dysfunction represents the most important cause of death in patients with paracoccidioidomycosis (PBM). In order to investigate the functional changes of the lungs in the early stages of PBM, a model of benign disease was developed by intratracheal challenge of 12-week old isogenic Wistar rats with 1 x 106 yeast forms of Paracoccidioides brasiliensis. Animals were studied 30 and 60 days after infectio...

Pregnancy and endocrinopathy. Activity, pathology and results at the outpatient...

The authors have elaborated a statistic survey about the pregnant women with endocrinopathies, that they have examined in the outpatient clinic from January of 1980 to December of 1988. Three hundred and twenty four women were examined in an amount of 2152 (two thousand one hundred and fifty two) observations. The incidence for 100 births was 0.54%. Maternal and fetal mobility and mortality were analysed in cor...

Diabetes mellitus and pregnancy--treatment.

Correct treatment of diabetes during pregnancy is of utmost importance, in the previously diabetic woman as well as in gestational diabetes. It is aimed at avoiding consequences of the metabolic disturbances on the mother and the fetus. Intensive insulin therapy and correct food intake are the cornerstones of treatment, euglycaemia without hypoglycaemic reactions or ketosis being their goal. ; Correct treatmen...