Human immunodeficiency virus type 1 recombinant B/G subtypes circulating in Coi...

• Author(s): Duque, V ; Holguín, A ; Meliço-Silvestre, A ; Gonzáles-Lahoz, J ; Soriano, V
• Date: 2003
• Persistent ID: http://hdl.handle.net/10400.4/297
• Origin: Repositório do Centro Hospitalar e Universitário de Coimbra
• Subject(s): HIV-1; Infecção por HIV; Recombinação Genética
• Document Type: Article
• Language: English

Description

An increasing prevalence of HIV-1 non-B variants is being noticed in several European regions, particularly in countries such as Portugal, which have closer contacts with African endemic areas, where multiple HIV subtypes cocirculate. HIV-1 subtyping by phylogenetic analyses of reverse transcriptase, protease and env (C2-V3) genomic regions was carried out in plasma collected from 18 HIV-1-infected subjects living in Coimbra, Portugal, and suspected to be infected with non-B variants. Three (16.7%) subjects carried recombinant B/G viruses (BV3/BRT/Gpro; GV3/URT/Bpro; AV3/GRT/Bpro), whereas all the remaining individuals were infected with HIV-1 subtype B. This is the first report of recombinant B/G subtypes in Portugal.