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First report of acute autochthonous hepatitis E in Portugal
Duque, V; Ventura, C; Seixas, D; Saraiva da Cunha, JG; Meliço-Silvestre, AHepatitis E infection is usually a self-limiting disease. In industrialized countries, sporadic cases of acute hepatitis E virus (HEV) infections have been described; their number seems to be increasing in European countries. We report the first human case of autochthonous acute hepatitis E confirmed in Portugal. Patients with acute non-A-C hepatitis should be tested for HEV in Portugal and hepatitis E infectio...
Plasmodium falciparum malaria, bilateral sixth cranial nerve palsy and delayed ...
Duque, V; Seixas, D; Ventura, C; Saraiva da Cunha, JG; Meliço-Silvestre, AWe describe the case of a 14-year-old Caucasian male, a resident in the Democratic Republic of the Congo, who was observed in Portugal with severe Plasmodium falciparum malaria with high-level parasitemia and severe thrombocytopenia. The course was complicated by bilateral sixth cranial nerve palsy during acute malaria, followed by the appearance of delayed cerebellar ataxia during the recovery phase. This occu...
Clinical manifestations of pandemic (H1N1) 2009 in the ambulatory setting
Duque, V; Vaz, J; Morais, V; Saraiva da Cunha, JG; Meliço-Silvestre, AINTRODUCTION: In June 2009, the World Health Organization declared an influenza pandemic associated with the pandemic (H1N1) 2009 strain. It was summer in the northern hemisphere, and therefore travelling and vacation time, which also provided an increased opportunity for the dissemination of respiratory diseases. METHODOLOGY: We reviewed the paper case report forms from all the patients with influenza-like il...
Mediterranean spotted fever and encephalitis: a case report and review of the l...
Duque, V; ventura, C; Seixas, D; Barai, A; Mendonça, N; Martins, J; Saraiva da Cunha, JG; Meliço-Silvestre, AMediterranean spotted fever (MSF) is a disease caused by Rickettsia conorii and transmitted by the brown dog tick Rhipicephalus sanguineus. It is widely distributed through southern Europe, Africa, and the Middle East. It is an emerging or a reemerging disease in some regions. Countries of the Mediterranean basin, such as Portugal, have noticed an increased incidence of MSF over the past 10 years. It was believ...
Os dias iniciais da infecção pelo vírus da gripe pandémica (H1N1) 2009 na regiã...
Duque, V; Cordeiro, E; Mota, V; Morais, C; Rodrigues, F; Coelho, F; Saraiva da Cunha, JG; Meliço-Silvestre, ABACKGROUND: The first case of pandemic (H1N1) 2009 virus infection was diagnosed in the central region of Portugal on June 16, 2009, in a woman infected in Canada. METHODS: The aim of our study was, first to characterize the clinical and epidemiologic aspects of all the patients with clinical manifestations included in the definition of case for investigation with samples submitted to diagnosis of the pandemic...
Detection of the protease codon 35 amino acid insertion in sequences from treat...
Pereira-Vaz, J; Duque, V; Trindade, L; Saraiva da Cunha, JG; Meliço-Silvestre, ABACKGROUND: Amino acids insertions in the protease (PR) coding region have been reported in protease inhibitors (PIs) treatment-naïve and experienced HIV-1 infected individuals ranging from 0.1% to 4.55% and have been rarely found in non-B HIV-1 subtype strains. OBJECTIVES: To investigate the presence of amino acid insertions in the PR coding region in sequences from treatment-naïve HIV-1 infected individuals ...
Human immunodeficiency virus type 1 recombinant B/G subtypes circulating in Coi...
Duque, V; Holguín, A; Meliço-Silvestre, A; Gonzáles-Lahoz, J; Soriano, VAn increasing prevalence of HIV-1 non-B variants is being noticed in several European regions, particularly in countries such as Portugal, which have closer contacts with African endemic areas, where multiple HIV subtypes cocirculate. HIV-1 subtyping by phylogenetic analyses of reverse transcriptase, protease and env (C2-V3) genomic regions was carried out in plasma collected from 18 HIV-1-infected subjects liv...
The treatment of cytomegalovirus retinitis in human immunodeficiency virus infe...
Rabadão, E; Departamento de Doenças Infecciosas, Hospitais da Universidade de Coimbra.; Duque, V; Meliço-Silvestre, AMost of the patients with immunodeficiency virus infection (75%-85%) are coinfected with cytomegalovirus. It is estimated that cytomegalovirus disease develops in 45% of them, mainly those presenting low CD4 cell counts (< 100/mm3). Retinitis is the most common manifestation of reactivated cytomegalovirus disease (85%), followed by other extra ocular sites (central nervous system, lungs, gastrointestinal system...
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