Nefropatia diabética: taxa de filtração glomerular calculada e estimada

• Author(s): Guimarães, J ; Bastos, M ; Melo, M ; Carvalheiro, M
• Date: 2007
• Persistent ID: http://hdl.handle.net/10400.4/212
• Origin: Repositório do Centro Hospitalar e Universitário de Coimbra
• Subject(s): Creatinina; Diabetes Mellitus Tipo 1; Diabetes Mellitus Tipo 2; Taxa de Filtração Glomerular
• Document Type: Article
• Language: Portuguese

Description

OBJECTIVE: To assess in diabetic nephropathy, the accuracy of estimated creatinine clearance (calculated with the Cockroft Gault formula) and the clearance of the Tc99m-DTPA, to measure the glomerular filtration rate (GFR). PATIENTS AND METHODS: We analysed the GFR measure by Tc99m-DTPA method and the estimated by the Cockroft Gault formula, in 21 subjects with type 1 or type 2 diabetes. RESULTS: There was a strong positive correlation between the two methods but the Cockroft Gault formula underestimated the GFR. CONCLUSIONS: The formula gives a accurate estimates of GFR, when GFR is <100 ml/min/1,73 m2. Beside the underestimation, the formula could be used in the management of diabetic nephropathy because the repeated isotope assessments of renal function are impracticable.