Vaccination models and optimal control strategies to dengue

• Autor(es): Rodrigues, Helena Sofia ; Monteiro, M. Teresa T. ; Torres, Delfim F. M.
• Data: 2013
• Identificador Persistente: http://hdl.handle.net/1822/25779
• Origem: RepositóriUM - Universidade do Minho
• Assunto(s): Dengue; Vaccine; SVIR model; Optimal control
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

"accepted 16-Oct-2013" As the development of a dengue vaccine is ongoing, we simulate an hypothetical vaccine as an extra protection to the population. In a rst phase, the vaccination process is studied as a new compartment in the model, and di erent ways of distributing the vaccines investigated: pediatric and random mass vaccines, with distinct levels of e cacy and durability. In a second step, the vaccination is seen as a control variable in the epidemiological process. In both cases, epidemic and endemic scenarios are included in order to analyze distinct outbreak realities