Hormonal contraceptives and the length of their use are not independent risk fa...

• Autor(es): Longatto Filho, Adhemar ; Hammes, L. Serpa ; Sarian, L. ; Roteli-Martins, C. ; Derchain, S. ; Eržen, M. ; Branca, M. ; Tatti, S. ; Naud, P. ; Matos, J. C. ; Gontijo, R. ; Maeda, Marina Yoshiê Sakamoto ; Lima, Temístocles ; Costa, S. ; Syrjänen, S. ; Syrjänen, K.
• Data: 2010
• Identificador Persistente: http://hdl.handle.net/1822/25632
• Origem: RepositóriUM - Universidade do Minho
• Assunto(s): Hormonal contraceptives; Cervical intraepithelial lesions; High-risk human papillomavirus; Cohort study
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

AIMS: To evaluate the role of hormonal contraceptives as a risk factor of high-risk human papillomavirus (HR-HPV), cervical intraepithelial lesions (CIN) and cervical cancer in our multi-center population-based LAMS (Latin American Screening) study. METHODS: A cohort study with >12,000 women from Brazil and Argentina using logistic regression to analyze the covariates of hormonal contraception (HOC - oral, injections, patches, implants, vaginal ring and progesterone intrauterine system) use followed by multivariate modeling for predictors of HR-HPV and CIN2+. RESULTS: HR-HPV infection was a consistent risk factor of high-grade CIN in all three groups of women. The length of HOC use was not significantly related to high-grade squamous intraepithelial lesions (HSIL)+ Pap (p = 0.069), LSIL+ Pap (p = 0.781) or ASCUS+ (p = 0.231). The same was true with the length of HOC use and histology CIN3+ (p = 0.115) and CIN2+ (p = 0.515). Frequently, HOC users have previously shown more HPV-related lesions, as well as lower HPV prevalence if they were current smokers. But HOC use and time of usage were not independent risk factors of either HR-HPV infection or high-grade CIN using multiple logistic regressions. CONCLUSIONS: No evidence was found for an association between the use of HOC with an increased risk for HR-HPV infection or high-grade CIN in this cohort.