MicroRNA history : discovery, recent applications and next frontiers

• Autor(es): Almeida, Maria Inês ; Reis, R. M. ; Calin, George A.
• Data: 2012
• Identificador Persistente: http://hdl.handle.net/1822/18666
• Origem: RepositóriUM - Universidade do Minho
• Assunto(s): MicroRNAs; History; Cancer
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

We thank the Department of Scientific Publications at The University of Texas MD Anderson Cancer Center for English language editing of the manuscript. Since 1993, when the first small non-coding RNA was identified, our knowledge about microRNAs has grown exponentially. In this review, we focus on the main progress in this field and discuss the most important findings under a historical perspective. In addition, we examine microRNAs as markers ofdisease diagnosis and prognosis, and as new therapeutic targets.