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Long non-coding RNAs and cancer : a new frontier of translational research?
Spizzo, Riccardo; Almeida, Maria Inês; Colombatti, A.; Calin, George A.Author manuscript ; Tiling array and novel sequencing technologies have made available the transcription profile of the entire human genome. However, the extent of transcription and the function of genetic elements that occur outside of protein-coding genes, particularly those involved in disease, are still a matter of debate. In this review, we focus on long non-coding RNAs (lncRNAs) that are involved in canc...
Modulation of MicroRNA-194 and cell migration by HER2-targeting trastuzumab in ...
Le, Xiao-Fen; Almeida, Maria Inês; Mao, Weiqu; Spizzo, Riccardo; Rossi, Simona; Nicoloso, Milena S.; Zhang, Shu; Wu, Yun; Calin, George A.Conceived and designed the experiments: XFL GAC RCB. Performed the experiments: XFL MIA WM RS MSN SZ. Analyzed the data: XFL SR. Contributed reagents/materials/analysis tools: YW GAC. Wrote the paper: XFL RCB. ; Trastuzumab, a humanized monoclonal antibody directed against the extracellular domain of the HER2 oncoprotein, can effectively target HER2-positive breast cancer through several mechanisms. Although t...
Decoy activity through microRNAs : the therapeutic implications
Almeida, Maria Inês; Reis, R. M.; Calin, George A.Introduction: microRNAs (miRNAs), small noncoding RNAs, are deregulated in several diseases including cancer. miRNAs regulate gene expression at a posttranscriptional level by binding to 5´UTR, coding regions or 3´UTR of messenger RNAs (mRNA), inhibiting mRNA translation or causing mRNA degradation. The same miRNA can have multiple mRNA targets, and the same mRNA can be regulated by various miRNAs. Areas covere...
Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal can...
Almeida, Maria L.; Nicoloso, Milena S.; Zeng, Lizhi; Ivan, Cristina; Spizzo, Riccardo; Gafà, Roberta; XIiao, LIianchun; Zhang, Xinna; Vanninii, IvanThe authors thank Sue Moreau from the Department of Scientific Publications at The University of Texas MD Anderson Cancer Center for English language editing of the manuscript. Author contributions: Study concept and design: M.I.A., P.A.Z, G.A.C. Acquisition of data: M.I.A., L.Z., X.Z. Drafting of the manuscript: M.I.A., M.N., R.S., M.F., R.M.R., P.A.Z, G.A.C. Analysis and interpretation of data: M.I.A., M.N., ...
MicroRNA history : discovery, recent applications and next frontiers
Almeida, Maria Inês; Reis, R. M.; Calin, George A.We thank the Department of Scientific Publications at The University of Texas MD Anderson Cancer Center for English language editing of the manuscript. ; Since 1993, when the first small non-coding RNA was identified, our knowledge about microRNAs has grown exponentially. In this review, we focus on the main progress in this field and discuss the most important findings under a historical perspective. In addit...
BRCA1, microRNAs and cancer predisposition : challenging the dogma
Almeida, Maria Inês; Reis, R. M.; Calin, George A.The importance of SNPs in conveying susceptibility to different kinds of cancer. The study by Pelletier et al. (2011) is particularly vital because it describes new genetic markers in BRCA1 3’UTR noncoding regions that can improve our determination of breast cancer susceptibility. Inclusion of these SNPs in BRCA1 haplotypes that are associated with breast cancer risk may guide future studies of functional miRNA...
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