Synthesis of novel benzofurocoumarin analogues and their anti-proliferative eff...

• Author(s): Francisco, Carla S. ; Rodrigues, L. R. ; Cerqueira, N. M. F. S. A. ; Campos, Ana M. F. Oliveira ; Rodrigues, Lígia M.
• Date: 2012
• Persistent ID: http://hdl.handle.net/1822/16410
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Benzofurocoumarins;; Benzopsoralen analogues; Antitumour activity; Docking; Computational studies
• Document Type: Article
• Language: English

Description

The synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumour cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma)) were evaluated, and discussed in terms of structure–activity relationship.