BRCA1, microRNAs and cancer predisposition : challenging the dogma

• Autor(es): Almeida, Maria Inês ; Reis, R. M. ; Calin, George A.
• Data: 2011
• Identificador Persistente: http://hdl.handle.net/1822/15061
• Origem: RepositóriUM - Universidade do Minho
• Assunto(s): Tumor suppressor gene; BRCA1; Single-nucleotide polymorphism (SNP); Functional miRNA interactions
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

The importance of SNPs in conveying susceptibility to different kinds of cancer. The study by Pelletier et al. (2011) is particularly vital because it describes new genetic markers in BRCA1 3’UTR noncoding regions that can improve our determination of breast cancer susceptibility. Inclusion of these SNPs in BRCA1 haplotypes that are associated with breast cancer risk may guide future studies of functional miRNA interactions and their cellular consequences. This has the potential to greatly increase our ability to diagnose BRCA1-negative breast cancer at an earlier stage.