Document details

BRCA1, microRNAs and cancer predisposition : challenging the dogma

Author(s): Almeida, Maria Inês cv logo 1 ; Reis, R. M. cv logo 2 ; Calin, George A. cv logo 3

Date: 2011

Persistent ID: http://hdl.handle.net/1822/15061

Origin: RepositóriUM - Universidade do Minho

Subject(s): Tumor suppressor gene; BRCA1; Single-nucleotide polymorphism (SNP); Functional miRNA interactions


Description
The importance of SNPs in conveying susceptibility to different kinds of cancer. The study by Pelletier et al. (2011) is particularly vital because it describes new genetic markers in BRCA1 3’UTR noncoding regions that can improve our determination of breast cancer susceptibility. Inclusion of these SNPs in BRCA1 haplotypes that are associated with breast cancer risk may guide future studies of functional miRNA interactions and their cellular consequences. This has the potential to greatly increase our ability to diagnose BRCA1-negative breast cancer at an earlier stage.
Document Type Article
Language English
delicious logo  facebook logo  linkedin logo  twitter logo 
degois logo
mendeley logo

Related documents



    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento EU