Unnatural benz-X-azolyl asparagine derivatives as novel fluorescent amino acids...

• Autor(es): Esteves, Cátia I. C. ; Silva, Ana M. F. ; Raposo, M. Manuela M. ; Costa, Susana P. G.
• Data: 2009
• Identificador Persistente: http://hdl.handle.net/1822/10649
• Origem: RepositóriUM - Universidade do Minho
• Assunto(s): Asparagine; Unnatural amino acids; Benzothiazole; Fluorescent probes; Solvatochromism
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

A family of new asparagine derivatives bearing benzothiazole and benzimidazole units, functionalised with electron donor or acceptor groups, were synthesized in good to excellent yields. The photophysical characterization of these new heterocyclic amino acids was performed by UV-visible absorption and fluorescence emission studies and revealed that the compounds displayed remarkably high fluorescence quantum yields and Stokes’ shifts, making them good candidates for application as fluorescent probes by incorporation into peptidic frameworks.