Autor(es):
Pires, Isabel 
; Silva, F. ; Queiroga, F.L. ; Rodrigues, P. ; Henriques, R. ; Pinto, C.A. ; Lopes, C.
Data: 2010
Identificador Persistente: http://hdl.handle.net/10348/2721
Origem: Repositório da UTAD
Assunto(s): epithelioid hemangiosarcoma; immunohistochemistry; ultrastructure; urinary bladder; vascular neoplasm; cattle
Descrição
Epithelioid hemangiosarcoma is a specific variant of hemangiosarcoma that has recently been
recognized in domestic animals. These malignant vascular neoplasms histologically resemble, and may be
mistaken for, carcinomas. Four epithelioid hemangiosarcomas in the urinary bladders of 4 cows with severe
enzootic hematuria are described in the current study. Grossly, the vesicular mucosa of the urinary bladder of
each cow contained a single red elevated nodule. Histologically, each neoplasm was composed of short
strands, cords, or nests of epithelioid, round, or slightly spindle-shaped endothelial cells that formed small
vascular structures. Neoplastic cells were immunohistochemically positive for factor VIII–related antigen and
vimentin, and were negative for cytokeratin and desmin. Ultrastructurally, the neoplastic cells often contained
cytoplasmic intermediate filaments, a prominent granular endoplasmic reticulum, a Golgi complex,
mitochondria, marked pinocytotic activity, and rare Weibel-Palade bodies. These neoplasms were diagnosed
as epithelioid hemangiosarcomas based on their histologic, immunohistochemical, and ultrastructural
features. The present report widens the spectrum of mesenchymal tumors of the bovine urinary bladder and
aids in the characterization of these vascular neoplasms.
