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The HIF1A Functional Genetic Polymorphism at Locus +1772 Associates with Progre...

The hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. In this study we sought to evaluate the association of a functional genetic polymorphism in HIF1A with overall and metastatic prostate cancer (PCa) risk and with response to androgen deprivation therapy (ADT). The HIF...

Sialyl Tn-Expressing Bladder Cancer Cells Induce a Tolerogenic Phenotype in Inn...

Despite the wide acceptance that glycans are centrally implicated in immunity, exactly how they contribute to the tilt immune response remains poorly defined. In this study, we sought to evaluate the impact of the malignant phenotype-associated glycan, sialyl-Tn (STn) in the function of the key orchestrators of the immune response, the dendritic cells (DCs). In high grade bladder cancer tissue, the STn antigen ...

The HIF1A Functional Genetic Polymorphism at Locus +1772 Associates with Progre...

The hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. In this study we sought to evaluate the association of a functional genetic polymorphism in HIF1A with overall and metastatic prostate cancer (PCa) risk and with response to androgen deprivation therapy (ADT). The HIF...

Sinais em Radiologia Torácica

Alterações histológicas dos rins e expressão das metalotioneínas e das proteína...

The histological alterations and the expression of metallothionein (MTs) and heat shock protein (Hsp70) in the kidney of Wistar rats after thiram fungicide exposure were evaluated. Animals were distributed into three groups: standard diet group, standard diet + corn oil group and thiram group. Significant differences were found (P<0,05) in the evolution of body weight between rats in the thiram group and those ...

Physical characteristics of the eggs of red-legged partridge (Alectoris rufa) r...

The objective of the present study was to evaluate the effects of female age (1, 2 and 3-year-old) and month of laying (March, April and May) on the physical characteristics of the red-legged partridge eggs reared in captivity. O objetivo do presente estudo foi avaliar os efeitos da idade das fêmeas (um, dois e três anos) e do mês de postura (março, abril e maio) sobre as características físic...

Assessing foraging strategies of herbivores in Mediterranean oak woodlands: a r...

Montados are agro-silvo-pastoral ecosystems, typical of the Southwest Iberian Peninsula, of high socio-economic and conservation importance,where grazing is a dominant activity. Montados are characterized by na open tree canopy of Quercus sp. and a diverse undercover of shrubs and grasslands that constitute the plant food resources for grazing animals. Plant food resources of Montados are highly variable, both ...

In vivo and in vitro heat shock proteins gene expression in cattle.

The main purpose for this study was the quantification of the heat shock proteins HSPA1A and HSP90AA1, in cow lymphocytes, when subjected to heat stress directly - in vivo, or indirectly - in vitro. The aim was to identify differences between HSP expression in vitro and in vivo. The experiment was conducted in the Biometeorology and Ethology Laboratory of FZEA-USP. Were used three female Holstein Frisian, which...

Analysis of pancreas histological images for glucose intolerance identification...

The observation in microscopy of histological sections allows us to evaluate structural differences, in pancreatic cells, between rats with normal glucose tolerance and with glucose intolerance (pre-diabetic) situation. Nevertheless, this pre-diabetic condition implies subtle changes in islets of Langerhans structure. This and the normal variability among sampled cells makes difficult the task of identifying gl...

Coriorretinopatia central serosa: uma revisão