Squaric acid: a valuable scaffold for developing antimalarials?

• Author(s): Kumar, S. Praveen ; Glória, Paulo M. C. ; Gonçalves, Lídia M. ; Gut, Jiri ; Rosenthal, Philip J. ; Moreira, Rui ; Santos, Maria M. M.
• Date: 2012
• Persistent ID: http://hdl.handle.net/10451/9635
• Origin: Repositório da Universidade de Lisboa
• Document Type: Article
• Language: English

Description

We describe here the synthesis of a library of thirty-eight squaric derivatives and the evaluation of activity against papain-, falcipain-2- and a chloroquine-resistant strain of P. falciparum. The most active compounds combine significant antiplasmodial activity with minimal cytotoxicity.