Autor(es):
Silva-Nunes, José 
; Oliveira, Ana ; Duarte, Leone ; Barradas, Margarida ; Melão, Alice ; Brito, Miguel ; Veiga, Luísa
Data: 2013
Identificador Persistente: http://hdl.handle.net/10400.21/2615
Origem: Repositório Científico do Instituto Politécnico de Lisboa
Assunto(s): Obesity; Adiponectin; Adipokines; Lifestyle factors; Weight loss; Bariatric surgery; Endocrinology
Descrição
Objective: To assess different factors influencing adiponectinemia in obese and normal-weight women; to identify factors associated with the variation (Δ) in adiponectinemia in obese women following a 6-month weight loss program, according to surgical/non-surgical interventions. Methods: We studied 100 normal-weight women and 112 obese premenopausal women; none of them was on any medical treatment. Women were characterized for anthropometrics, daily macronutrient intake, smoking status, contraceptives use, adiponectin as well as IL-6 and TNF-α serum concentrations. Results: Adiponectinemia was lower in obese
women (p < 0.001), revealing an inverse association with waist-to-hip ratio (p < 0.001; r = –0.335). Normal-weight women presented lower adiponectinemia among smokers (p = 0.041); body fat, waist-to-hip ratio, TNF-α levels, carbohydrate intake, and smoking all influence adiponectinemia (r 2 = 0.436). After weight loss interventions, a significant modification in macronutrient
intake occurs followed by anthropometrics decrease (chiefly after bariatric procedures)
and adiponectinemia increase (similar after surgical and non-surgical interventions).
After bariatric intervention, Δ adiponectinemia was inversely correlated to Δ waist circumference and Δ carbohydrate intake (r 2 = 0.706). Conclusion: Anthropometrics, diet, smoking, and TNF-α levels all influence adiponectinemia in normal-weight women, although explaining less
than 50% of it. In obese women, anthropometrics modestly explain adiponectinemia. Opposite to non-surgical interventions, after bariatric surgery adiponectinemia increase is largely explained by diet composition and anthropometric changes.
