Document details

Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma ...

Author(s): Botelho, Mónica C. cv logo 1 ; Oliveira, Paula A. cv logo 2 ; Vieira, Paulo cv logo 3 ; Delgado, Maria de Lurdes cv logo 4 ; Lourenço, Ligia cv logo 5 ; Lopes, Carlos cv logo 6 ; Machado, José C . cv logo 7 ; Costa, José M Correia da cv logo 8

Date: 2010

Persistent ID: http://hdl.handle.net/10400.18/199

Origin: Repositório Científico do Instituto Nacional de Saúde

Subject(s): Schistosoma haematobium; Adult worms; Liver lesions; Liver fibrosis; Infecções Sistémicas e Zoonoses


Description
Golden hamsters were inoculated with Schistosoma haematobium cercariae to examine histological lesions at different time points over an 18 month period of infection. Hamsters were sacrificed 26 weeks and 82 weeks after inoculation. The parasite was found in the blood and in the liver of infected animals as was expected, but we found exclusively male worms, no female worms nor eggs. Interestingly we observed unexpected hepatic lesions induced by S. haematobium immature male worms alone in the golden hamster, characteristic of schistosome eggs. Samples from liver, kidneys, lungs, bladder and gastrointestinal tract were collected during necropsy to evaluate injuries induced by S. haematobium. Notably we observed hepatitis in the liver of infected hamsters, no lesions were found in other organs. We also found liver fibrosis in infected hamsters. This study provides further experimental evidence for the role that schistosome worms, and their derived antigens, may play in the pathology of the infection and modulation of liver chronic inflammation in the murine model of schistosomiasis.
Document Type Article
Language English
delicious logo  facebook logo  linkedin logo  twitter logo 
degois logo
mendeley logo

Related documents



    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento EU