A whole genome screen for association with multiple sclerosis in Portuguese pat...

• Autor(es): Santos, M ; Pinto-Basto, J ; Rio, ME ; Sá, MJ ; Valença, A ; Sá, A ; Dinis, J ; Figueiredo, J ; Bigotte de Almeida, L ; Coelho, I ; Sawcer, S ; Setakis, E ; Compston, A ; Sequeiros, J ; Maciel, P
• Data: 2003
• Identificador Persistente: http://hdl.handle.net/10400.23/540
• Origem: Repositório Científico do Hospital de Braga
• Assunto(s): Predisposição Genética para Doença; Portugal; Esclerose Múltipla; Testes Genéticos
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n=188) and matched controls (n=188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.