HUMAN BLOOD T AND NK CELL IN VITRO STIMULATION REVEALS A SIMILAR ACTIVATION PHE...

• Author(s): Moura, J. ; Gonçalves, M: ; Fonseca, S. ; Santos, A. ; Queirós, M. ; Teixeira, M. ; Lima, M.
• Date: 2009
• Persistent ID: http://hdl.handle.net/10400.16/326
• Origin: Repositório Científico do Centro Hospitalar do Porto
• Document Type: Conference Object
• Language: English

Description

The complexity of T and NK-cell responses needs a great deal of control in the way these cells respond to stimulation. This is made by a precise regulation of gene expression leading to specific changes of membrane proteins, in order to acquire their full cytotoxic or immunological mediators secreting potential. The immunophenotypic changes occurring in-vivo on blood T and NK-cells in patients with acute and chronic infections have been previously characterized in detail, defining early and late activation related phenotypes, but in-vitro experiments are needed to define the earliest activation stages.