HUMAN BLOOD T AND NK CELL IN VITRO STIMULATION REVEALS A SIMILAR ACTIVATION PHE...

• Autor(es): Moura, J. ; Gonçalves, M: ; Fonseca, S. ; Santos, A. ; Queirós, M. ; Teixeira, M. ; Lima, M.
• Data: 2009
• Identificador Persistente: http://hdl.handle.net/10400.16/326
• Origem: Repositório Científico do Centro Hospitalar do Porto
• Tipo de Documento: Documento de conferência
• Idioma: Inglês

Descrição

The complexity of T and NK-cell responses needs a great deal of control in the way these cells respond to stimulation. This is made by a precise regulation of gene expression leading to specific changes of membrane proteins, in order to acquire their full cytotoxic or immunological mediators secreting potential. The immunophenotypic changes occurring in-vivo on blood T and NK-cells in patients with acute and chronic infections have been previously characterized in detail, defining early and late activation related phenotypes, but in-vitro experiments are needed to define the earliest activation stages.