CHEMOKINE RECEPTOR REPERTOIRE REFLECTS MATURE T-CELL LYMPHOPROLIFERATIVE DISORD...

• Author(s): Moura, J. ; Rodrigues, J. ; Santos, A. ; Teixeira, M. ; Queirós, M. ; Santos, M. ; Gonçalves, M. ; Fonseca, S. ; Laranjeira, C. ; Ribeiro, F. ; Acosta, M. ; Rodrigues, A. ; Júnior, E. ; Lima, M.
• Date: 2009
• Persistent ID: http://hdl.handle.net/10400.16/323
• Origin: Repositório Científico do Centro Hospitalar do Porto
• Document Type: Conference Object
• Language: English

Description

The World Health Organisation classification of mature T-cell lymphoproliferative disorders, combines clinical, morphological and immunophenotypic data. The later majorly contributes for the classification, as well as to the understanding of the malignant T-cell behaviour. The fact that T-cell migration is regulated by chemokines should, in theory, enable us to identify tissue tropism and organ involvement by neoplastic Tcells, through monitoring of chemokine receptor surface expression.