Successful Handling of Disseminated BCG Disease in a Child with Severe Combined...

• Author(s): Bacalhau, S ; Freitas, C ; Valente, R ; Barata, D ; Neves, C ; Schäfer, K ; Lubatschofski, A ; Schulz, A ; Farela Neves, J
• Date: 2011
• Persistent ID: http://hdl.handle.net/10400.17/1566
• Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
• Subject(s): BCG; Recém-Nascido; Imunodeficiência Combinada Severa; HDE UCI PED; HDE INF PED
• Document Type: Article
• Language: English

Description

In high-burden countries, Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severe Mycobacterium tuberculosis infection. Because life-threatening disseminated BCG disease may occur in children with primary immunodeficiency, vaccination strategy against tuberculosis should be redefined in non-high-burden countries. We report the case of a patient with X-linked severe combined immunodeficiency (SCID) who developed disseminated BCG disease, highlighting the specific strategies adopted.