Using Radiobiology Simulators for Evaluation of 99mTc Auger Electrons for Targe...

• Author(s): Adriana Alexandre S. Tavares ; João Manuel R. S. Tavares
• Date: 2010
• Persistent ID: http://hdl.handle.net/10216/39344
• Origin: Repositório Aberto da Universidade do Porto
• Subject(s): Ciências tecnológicas; Engenharia; Engenharia biomédica
• Document Type: Conference Object
• Language: English

Description

Technetium-99m (99mTc) has been widely used as an imaging agent; however, few studies evaluated its potential use as therapeutic agent. The present study aimed to analyze the potential use of 99mTc Auger electrons for targeted tumor radiotherapy by computational methods. Thus, three different computational simulators were used to estimate the yield of DNA damage, the probability of correct repair and cell kinetic effects after irradiation with 99mTc electrons, iodine-131 beta minus particles and astatine-211 alpha par-ticles. Based on the obtained results, it is possible to conclude that 99mTc CKMMX (all M-shell Coster-Kroning – CK – and super CK transitions) electrons and Auger MXY (all M-shell Auger transitions) are valuable for targeted tumor radiotherapy.