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Computational modelling of cellular effects post-irradiation with low- and high...
Adriana Alexandre S. Tavares; João Manuel R. S. TavaresThe use of computational methods to improve the understanding of biological responses to various types of radiation is an approach, where multiple parameters can be modelled and a variety of data is generated. This study compares cellular effects modelled for low absorbed doses against high absorbed doses. The authors hypothesized that low and high absorbed doses would contribute to cell killing via different m...
99mTc Auger Electrons - Analysis on the Effects of Low Absorbed Doses by Comput...
Adriana Alexandre S. Tavares; João Manuel R. S. TavaresWe describe here the use of computational methods for evaluation of the low dose effects on human fibroblasts after irradiation with Technetium-99m (99mTc) Auger electrons. The results suggest a parabolic relationship between the irradiation of fibroblasts with 99mTc Auger electrons and the total absorbed dose. Additionally, the results on very low absorbed doses may be explained by the bystander effect, which ...
Using Radiobiology Simulators for Evaluation of 99mTc Auger Electrons for Targe...
Adriana Alexandre S. Tavares; João Manuel R. S. TavaresTechnetium-99m (99mTc) has been widely used as an imaging agent; however, few studies evaluated its potential use as therapeutic agent. The present study aimed to analyze the potential use of 99mTc Auger electrons for targeted tumor radiotherapy by computational methods. Thus, three different computational simulators were used to estimate the yield of DNA damage, the probability of correct repair and cell kinet...
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