Voltammetric quantification of fluoxetine: application to quality control and q...

• Author(s): Lencastre, Rui P. ; Delerue-Matos, Cristina ; Garrido, Jorge ; Borges, Fernanda ; Garrido, E. Manuela
• Date: 2006
• Persistent ID: http://hdl.handle.net/10400.22/4204
• Origin: Repositório Científico do Instituto Politécnico do Porto
• Subject(s): Fluoxetine; Square wave voltammetry; Oxidation; Quality control; Pharmaceutics
• Document Type: Article
• Language: English

Description

The oxidative behaviour of fluoxetine was studied at a glassy carbon electrode in various buffer systems and at different pH using cyclic, differential pulse and square wave voltammetry. A new square wave voltammetric method suitable for the quality control of fluoxetine in commercial formulations has been developed using a borate pH 9 buffer solution as supporting electrolyte. Under optimized conditions, a linear response was obtained in the range 10 to 16 μM with a detection limit of 1.0 μM. Validation parameters such as sensitivity, precision and accuracy were evaluated. The proposed method was successfully applied to the determination of fluoxetine in pharmaceutical formulations. The results were statistically compared with those obtained by the reference high-performance liquid chromatographic method. No significant differences were found between the methods.