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Electrochemical oxidation of tamoxifen revisited
Garrido, Jorge; Quezada, E.; Fajín, J. L. C.; Cordeiro, M. N. D. S.; Garrido, E. Manuela; Borges, FernandaTamoxifen is a selective estrogen receptor modulator that is used as an adjuvant and/or chemotherapeutic agent for the treatment of all stages of hormone-dependent breast cancer. Currently there is a deep interest in the study of tamoxifen biotransformation and identification of metabolites since they can significantly contribute to the overall pharmacological or adverse effects of the drug. Accordingly, the st...
Exploring nature profits: development of novel and potent lipophilic antioxidan...
Teixeira, José; Silva, Tiago; Benfeito, Sofia; Gaspar, Alexandra; Garrido, E. Manuela; Garrido, Jorge; Borges, FernandaPhenolic acids are ubiquitous antioxidants accounting for approximately one third of the phenolic compounds in our diet. Their importance was supported by epidemiological studies that suggest an inverse relationship between dietary intake of phenolic antioxidants and the occurrence of diseases, such as cancer and neurodegenerative disorders. However, until now, most of natural antioxidants have limited therapeu...
Hydroxycinnamic acid antioxidants: an electrochemical overview
Teixeira, José; Gaspar, Alexandra; Garrido, E. Manuela; Garrido, Jorge; Borges, FernandaHydroxycinnamic acids (such as ferulic, caffeic, sinapic, and p-coumaric acids) are a group of compounds highly abundant in food that may account for about one-third of the phenolic compounds in our diet. Hydroxycinnamic acids have gained an increasing interest in health because they are known to be potent antioxidants. These compounds have been described as chain-breaking antioxidants acting through radical sc...
Photostabilization of phenoxyacetic acid herbicides MCPA and mecoprop by hydrox...
Costa, Cátia; Maia, Sílvia; Silva, Paulo; Garrido, Jorge; Borges, Fernanda; Garrido, E. ManuelaNew strategies to reduce the environmental and economic costs of pesticides use are currently under study. Microencapsulation has been used as a versatile tool for the production of controlled release agricultural formulations. In this study, the photochemical degradation of the herbicides MCPA and mecoprop has been investigated in different aqueous media such as ultrapure and river water under simulated solar ...
Electrochemical determination of the herbicide bentazone using a carbon nanotub...
Rahemi, V.; Garrido, Jorge; Borges, Fernanda; Oliveira-Brett, A. M.; Garrido, E. ManuelaAn electrochemical sensor has been developed for the determination of the herbicide bentazone, based on a GC electrode modified by a combination of multiwalled carbon nanotubes (MWCNT) with b-cyclodextrin (b-CD) incorporated in a polyaniline film. The results indicate that the b-CD/MWCNT modified GC electrode exhibits efficient electrocatalytic oxidation of bentazone with high sensitivity and stability. A cycli...
Host-Guest interaction between herbicide oxadiargyl and hydroxypropyl-β-cyclode...
Benfeito, Sofia; Rodrigues, Tiago; Garrido, Jorge; Borges, Fernanda; Garrido, E. ManuelaIn the face of a growing human population and increased urbanization, the demand for pesticides will simply rise. Farmers must escalate yields on increasingly fewer farm acres. However, the risks of pesticides, whether real or perceived, may force changes in the way these chemicals are used. Scientists are working toward pest control plans that are environmentally sound, effective, and profitable. In this conte...
Fluoxetine and Norfluoxetine Revisited: New Insights into the Electrochemical a...
Garrido, E. Manuela; Garrido, Jorge; Calheiros, Rita; Borges, FernandaThe extent to which humans and wildlife are exposed to the vast array of anthropogenic chemicals and their degradation products, along with related naturally occurring compounds, is nowadays an important issue. The study of the physical-chemical properties of the compounds and/or degradation products is an important subject because some of them are intrinsically related to its resistance to degradation and/or b...
Voltammetric and DFT Studies on Viloxazine: Analytical Application to Pharmaceu...
Garrido, E. Manuela P. J.; Garrido, Jorge M. P. J.; Esteves, Mário; Santos-Silva, Alice; Marques, M. Paula M.; Borges, FernandaThe oxidative behavior of viloxazine was studied at a glassy carbon electrode in different buffer systems using cyclic, differential pulse and square-wave voltammetry. The oxidation process was shown to be diffusion-controlled and irreversible over the studied pH. The voltammetric study of the model compounds, 2-ethoxyanisole and morpholine, associated with quantum mechanical (DFT) calculations, allowed to eluc...
Voltammetric quantification of fluoxetine: application to quality control and q...
Lencastre, Rui P.; Delerue-Matos, Cristina; Garrido, Jorge; Borges, Fernanda; Garrido, E. ManuelaThe oxidative behaviour of fluoxetine was studied at a glassy carbon electrode in various buffer systems and at different pH using cyclic, differential pulse and square wave voltammetry. A new square wave voltammetric method suitable for the quality control of fluoxetine in commercial formulations has been developed using a borate pH 9 buffer solution as supporting electrolyte. Under optimized conditions, a lin...
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