Enthalpy of solution of terfenadine in ethanol/water mixtures

• Autor(es): Canotilho, João ; Costa, Felisbela S. ; Sousa, Adriano T. ; Redinha, J. Simões ; Leitão, M. Luísa P.
• Data: 2000
• Identificador Persistente: http://hdl.handle.net/10316/5813
• Origem: Estudo Geral - Universidade de Coimbra
• Assunto(s): Crystal design; Crystallization; Polymorphism; Solubility; Solute self-aggregation; Solution enthalpy; Terfenadine
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

The enthalpy of solution of terfenadine in ethanol/water mixtures, 0-20.5 wt.% of water was determined by calorimetry. A Sudden increase of 1-2 kJ mol-1 in the enthalpy at a concentration value around 0.01 mol kg-1 is observed. This step in the enthalpy is interpreted as due to solute n-mer aggregates formation. The solubility of terfenadine in the cosolvent systems used in the calorimetric studies was determined. http://www.sciencedirect.com/science/article/B6THV-3Y9X8C1-3/1/946cc8e5c8724eb5cab7f1c41b09d0f7