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Effect of solvent and temperature on solution-crystallized terfenadine

Leitão, M. Luísa P.; Canotilho, João; Ferreira, Simone C. R.; Sousa, Adriano T.; Redinha, J. Simões

The aim of this work was to understand the crystallization process of terfenadine in solution. ; http://www.sciencedirect.com/science/article/B6THV-49SWCDJ-1/1/bfcb0feff088fbe244525634b1e2dfda


Enthalpy of solution of terfenadine in ethanol/water mixtures

Canotilho, João; Costa, Felisbela S.; Sousa, Adriano T.; Redinha, J. Simões; Leitão, M. Luísa P.

The enthalpy of solution of terfenadine in ethanol/water mixtures, 0-20.5 wt.% of water was determined by calorimetry. A Sudden increase of 1-2 kJ mol-1 in the enthalpy at a concentration value around 0.01 mol kg-1 is observed. This step in the enthalpy is interpreted as due to solute n-mer aggregates formation. The solubility of terfenadine in the cosolvent systems used in the calorimetric studies was determin...


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