Electrochemical behaviour of isatin at a glassy carbon electrode

• Author(s): Diculescu, Victor C. ; Kumbhat, Sunita ; Oliveira-Brett, Ana Maria
• Date: 2006
• Persistent ID: http://hdl.handle.net/10316/5076
• Origin: Estudo Geral - Universidade de Coimbra
• Subject(s): Oxidation; Reduction; Voltammetry
• Document Type: Article
• Language: English

Description

The electrochemical behavior of isatin - a molecule with a broad range of applications in synthetic, biological and clinical activity - has been investigated over a wide pH range at a glassy carbon electrode (GCE) using cyclic, square wave and differential pulse voltammetry. The oxidation of isatin is an irreversible process, pH dependent and occurs with the formation of a main oxidation product that strongly adsorbs on the electrode surface. The reduction of isatin is also a pH dependent irreversible process. Cyclic voltammograms show two consecutive charge transfer reactions. The diffusion coefficient of isatin was calculated in pH 7.0 phosphate buffer to be D0 = 4.9 × 10-7 cm2 s-1. The limit of detection obtained in a solution of pH 7.0 phosphate buffer was LOD = 0.194 [mu]M, based on three times the noise level. http://www.sciencedirect.com/science/article/B6TF4-4K3N5RG-4/1/99ab4825e838a8e8c4bf07df3629ae82