Encontrados 11 documentos, a visualizar página 1 de 2
Evaluation of the structure–activity relationship of thrombin with thrombin bin...
Diculescu, Victor Constantin; Chiorcea-Paquim, Ana-Maria; Eritja, Ramon; Oliveira-Brett, Ana MariaThe structure–activity relationship of the complex between thrombin and thrombin binding aptamers (TBA) was evaluated by differential pulse voltammetry at a glassy carbon electrode and atomic force microscopy at a highly oriented pyrolytic graphite electrode. The effects on the interaction with thrombin of TBA primary and secondary structures as well as of its folding properties in the presence of alkaline meta...
Phenol And Para-Substituted Phenols Electrochemical Oxidation Pathways
Enache, Teodor Adrian; Oliveira-Brett, Ana MariaThe electrochemical behaviour of phenol, catechol, hydroquinone, resorcinol, dopamine, and para-substituted phenolic compounds, 4-ethylphenol, tyrosine, and tyramine, was studied over a wide pH range using a glassy carbon electrode. The oxidation of phenol is pH dependent and irreversible, occurring in one step, and followed by hydrolyse in ortho- and para- positions, leading to two oxidation products, catechol...
Metallo-functionalized first-generation salicylaldimine poly(propylenimine) tet...
Martinovic, Jasmina; Chiorcea-Paquim, Ana-Maria; Diculescu, Victor Constantin; Wyk, Juanita Van; Iwuoha, Emmanuel; Baker, Priscilla; Mapolie, SelwynThe adsorption and the redox processes of two first-generation salicylaldiamine dendritic ligands and their copper, cobalt and nickel metallo-functionalized complexes have been studied at two types of carbon electrode surface. Glassy carbon (GC) was used in an electrochemistry study and highly oriented pyrolitic graphite (HOPG) in ex situ atomic force microscopy (AFM) imaging. All salicylaldimine ligands and th...
Electrochemical Behavior of Thalidomide at a Glassy Carbon Electrode
Oliveira, S. Carlos B.; Vivan, Marilene; Oliveira-Brett, Ana MariaThalidomide is an oral drug marketed in the 1950s as a sedative and an anti-emetic during pregnancy that was removed from the market when its teratogenic side effects appeared in new born children due to inadequate tests to assess the drug's safety. Recent studies evaluating the use of thalidomide in cancer and HIV diseases have sparked renewed interest. The electrochemical behavior of thalidomide on a glassy c...
Electrochemical Oxidation of Metolazone at a Glassy Carbon Electrode
Pontinha, A. Dora R.; Oliveira, S. Carlos B.; Oliveira-Brett, Ana MariaMetolazone is a diuretic agent used in patients with edematous states and/or hypertension. The electrochemical behavior of metolazone on a glassy carbon electrode was investigated using cyclic, differential pulse, and square-wave voltammetry at different pHs. The pH dependent oxidation of metolazone occurs in two consecutive steps in a diffusion-controlled mechanism and involves the formation of a main oxidatio...
Electrochemical behaviour of 2,8-dihydroxyadenine at a glassy carbon electrode
Diculescu, Victor C.; Piedade, José António P.; Oliveira-Brett, Ana MariaThe electrochemical behaviour of 2,8-dihydroxyadenine (2,8-DHA)- the main adenine oxidation product- has been investigated over a wide pH range at a glassy carbon electrode (GCE) using cyclic, differential pulse and square wave voltammetry. ; http://www.sciencedirect.com/science/article/B6W72-4K0FG20-1/1/98da49a6d6213ae493b4562dd5599e49
Electrochemical behaviour of isatin at a glassy carbon electrode
Diculescu, Victor C.; Kumbhat, Sunita; Oliveira-Brett, Ana MariaThe electrochemical behavior of isatin - a molecule with a broad range of applications in synthetic, biological and clinical activity - has been investigated over a wide pH range at a glassy carbon electrode (GCE) using cyclic, square wave and differential pulse voltammetry. The oxidation of isatin is an irreversible process, pH dependent and occurs with the formation of a main oxidation product that strongly a...
Development of an HPLC method with electrochemical detection of femtomoles of 8...
Rebelo, Isabel A.; Piedade, José António P.; Oliveira-Brett, Ana MariaA selective method based on high performance liquid chromatography with electrochemical detection (HPLC-ECD) was developed to enable simultaneous detection of 8-oxo-7,8-dihydroguanine (8-oxoGua) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo), products of DNA oxidative damage, in the presence of uric acid (UA), a strong interferent in their electrochemical detection. The method developed consists of HPLC is...
Voltammetric and impedance studies of inosine-5'-monophosphate and hypoxanthine
Oliveira-Brett, Ana Maria; Silva, Luís A.; Farace, Giosi; Vadgama, Pankaj; Brett, Christopher M. A.The oxidation mechanism and adsorption of inosine 5'-monophosphate and hypoxanthine were investigated in solutions of different pH using voltammetric and impedance methods at glassy carbon electrodes. For both compounds, the pH dependence from differential pulse voltammetry showed that the same number of electrons and protons are involved in the rate-determining step of the electrochemical reaction. In the case...
Anodic voltammetry and AFM imaging of picomoles of adriamycin adsorbed onto car...
Oliveira-Brett, Ana Maria; Piedade, José António P.; Chiorcea, Ana-MariaAdriamycin adsorbs strongly and irreversibly onto surfaces and this enabled electrochemical detection of in situ adriamycin oxidative damage to DNA. The adsorption of adriamycin onto glassy carbon and highly oriented pyrolytic graphite (HOPG) electrodes was studied by voltammetry and mode atomic force microscopy (MAC). At a glassy carbon electrode (GCE), the adsorbate has similar voltammetric behaviour to adria...
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