Preparation and characterisation of gels based on sucrose modified with glycidy...

• Author(s): Ferreira, L. ; Vidal, M. M. ; Geraldes, C. F. G. C. ; Gil, M. H.
• Date: 2000
• Persistent ID: http://hdl.handle.net/10316/3836
• Origin: Estudo Geral - Universidade de Coimbra
• Subject(s): Sucrose; Glycidyl methacrylate; Swelling; Drug release
• Document Type: Article
• Language: English

Description

Sugar-based hydrogels were prepared by non-selective modification of sucrose with the introduction of vinyl groups. Sucrose was reacted with glycidyl methacrylate (1:1 molar ratio) in DMSO and in the presence of 4-(N,N-dimethylamino)pyridine (4-DMAP) as catalyst. The structure of the product (SucMA) was established using 1H NMR, 1H DQF-COSY NMR and 13C NMR analysis. Gels were prepared by copolymerisation of hydroxyethyl methacrylate (HEMA) and SucMA in a 70:30 ethylene glycol/water mixed solvent using ammonium persulphate/sodium methabisulphite pair as initiating system. The swelling behaviour of these gels was evaluated as a function of crosslinker content, copolymer composition, pH and ionic strength. In addition, the diffusional behaviour of sodium salycilate (SSA) from these gels and poly(HEMA) gels is also reported. http://www.sciencedirect.com/science/article/B6TFD-3XV2JTG-3/1/ad1327d644fe45111347ac202ea96c9b