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Design of a Drug-Delivery System Based On Polyacrylamide Hydrogels. Evaluation ...
Ferreira, L.; Vidal, M. M.; Gil, M. H.It is well known that hydrogels can be suitable for biomedical, agricultural, and industrial applications. In particular, they have been widely used for the preparation of drug-delivery systems. The preparation and characterization of such a system should be useful for introducing students to these materials. This paper describes the preparation of polyacrylamide hydrogels having different crosslinking densitie...
Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems a...
Ferreira, L.; Vidal, M. M.; Gil, M. H.Studies of dynamic and equilibrium swelling, structural characterisation and solute transport in swollen poly(2-hydroxyethyl methacrylate) gels (pHEMA) cross-linked with tripropyleneglycol diacrylate (TPGDA) were done for a wide range of TPGDA concentrations. The influence of the pH on these pHEMA properties was evaluated. In swelling studies it was found that in changing the pH from 6.5 to 12.0, a large increa...
Preparation and characterisation of gels based on sucrose modified with glycidy...
Ferreira, L.; Vidal, M. M.; Geraldes, C. F. G. C.; Gil, M. H.Sugar-based hydrogels were prepared by non-selective modification of sucrose with the introduction of vinyl groups. Sucrose was reacted with glycidyl methacrylate (1:1 molar ratio) in DMSO and in the presence of 4-(N,N-dimethylamino)pyridine (4-DMAP) as catalyst. The structure of the product (SucMA) was established using 1H NMR, 1H DQF-COSY NMR and 13C NMR analysis. Gels were prepared by copolymerisation of hyd...
Study of the thermal stability and enzymatic activity of an immobilised enzymat...
Vidal, M. M.; Gil, M. H.; Delgadillo, I.; Alonso, J.In this work, we have studied the immobilisation of the haemoglobin/glucose oxidase coupled enzymatic system in poly(vinyl alcohol) membranes. These are to be used as a reagent phase either in the development of an optical sensor or as an efficient bilirubin (BR) removal reactor. Poly(vinyl alcohol) (PVA) was chosen as the support for this purpose, due to its good biocompatibility, hydrophilicity and non-thromb...
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