Drug release assays from new chitosan/pHEMA membranes obtained by gamma irradia...

• Author(s): Casimiro, M. H. ; Gil, M. H. ; Leal, J. P.
• Date: 2007
• Persistent ID: http://hdl.handle.net/10316/3781
• Origin: Estudo Geral - Universidade de Coimbra
• Subject(s): Drug release; Gamma radiation, chitosan; Membranes; Amoxicillin
• Document Type: Article
• Language: English

Description

With the purpose of obtaining a biocompatible and microbiologically safe matrix that simultaneously could be used as wound dressing material and as a controlled drug release system, membranes with different thickness and different contents in chitosan and hydroxyethyl methacrylate (HEMA) have been prepared by [gamma] irradiation from a 60Co source. Antibiotic release experiments were performed before or after irradiation over amoxicillin loaded chitosan/pHEMA membranes in physiological saline solution, and monitored by UV-Vis spectrometry. http://www.sciencedirect.com/science/article/B6TJN-4PMJJX9-9/1/0b03eba841e57ba5c341c5bf1539b62c