Drug release assays from new chitosan/pHEMA membranes obtained by gamma irradia...

• Autor(es): Casimiro, M. H. ; Gil, M. H. ; Leal, J. P.
• Data: 2007
• Identificador Persistente: http://hdl.handle.net/10316/3781
• Origem: Estudo Geral - Universidade de Coimbra
• Assunto(s): Drug release; Gamma radiation, chitosan; Membranes; Amoxicillin
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

With the purpose of obtaining a biocompatible and microbiologically safe matrix that simultaneously could be used as wound dressing material and as a controlled drug release system, membranes with different thickness and different contents in chitosan and hydroxyethyl methacrylate (HEMA) have been prepared by [gamma] irradiation from a 60Co source. Antibiotic release experiments were performed before or after irradiation over amoxicillin loaded chitosan/pHEMA membranes in physiological saline solution, and monitored by UV-Vis spectrometry. http://www.sciencedirect.com/science/article/B6TJN-4PMJJX9-9/1/0b03eba841e57ba5c341c5bf1539b62c