Synthesis and evaluation of novel 17-indazole androstene derivatives designed a...

• Author(s): Moreira, Vânia M. A. ; Vasaitis, Tadas S. ; Njar, Vincent C. O. ; Salvador, Jorge A. R.
• Date: 2007
• Persistent ID: http://hdl.handle.net/10316/2792
• Origin: Estudo Geral - Universidade de Coimbra
• Subject(s): Indazole; CYP17; Prostate cancer; Androgen receptor; PC cell lines
• Document Type: Article
• Language: English

Description

A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17 -hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.