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Synthesis and evaluation of novel 17-indazole androstene derivatives designed a...
Moreira, Vânia M. A.; Vasaitis, Tadas S.; Njar, Vincent C. O.; Salvador, Jorge A. R.A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17 -hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.
Synthesis and evaluation of novel 17-indazole androstene derivatives designed a...
Moreira, Vânia M. A.; Vasaitis, Tadas S.; Njar, Vincent C. O.; Salvador, Jorge A. R.A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17[alpha]-hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines. ; http://www.sciencedirect.com/science/article/B6TC9-4PF1WHS-2/1/094a9de6c64...
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