Autor(es):
Rosa, Susana C. 
; Gonçalves, Juliana ; Judas, Fernando ; Mobasheri, Ali ; Lopes, Celeste ; Mendes, Alexandrina F.
Data: 2009
Identificador Persistente: http://hdl.handle.net/10316/11789
Origem: Estudo Geral - Universidade de Coimbra
Assunto(s): diabetes mellitus; osteoartrite
Descrição
Introduction Disorders that affect glucose metabolism, namely
diabetes mellitus (DM), may favor the development and/or
progression of osteoarthritis (OA). Thus far, little is known
regarding the ability of chondrocytes to adjust to variations in the
extracellular glucose concentration, resulting from hypoglycemia
and hyperglycemia episodes, and so, to avoid deleterious
effects resulting from deprivation or intracellular accumulation of
glucose. The aim of this study was to compare the ability of
normal and OA chondrocytes to regulate their glucose transport
capacity in conditions of insufficient or excessive extracellular
glucose and to identify the mechanisms involved and eventual
deleterious consequences, namely the production of reactive
oxygen species (ROS). 1Center for Neurosciences and Cell Biology, and Faculty of Pharmacy, University of Coimbra, 3004-517 Coimbra, Portugal
2Orthopaedics Department, University Hospital of Coimbra, Avenida Bissaya Barreto, Bloco de Celas, 3000-075 Coimbra, Portugal
3Division of Veterinary Medicine, School of Veterinary Science and Medicine, Sutton Bonington Campus, University of Nottingham, Sutton Bonington
LE12 5RD, UK
