Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina ; O vírus da imunodeficiência humana (HIV), para completar o seu ciclo de vida necessita de integrar o seu genoma no genoma humano, sendo que esta integração é feita em locais específicos. Ainda não estão completamente clarificadas as preferências de integração do HIV, por isso o nosso objectivo é estudar estas preferências utiliza...
In the last decades nanodiamonds have received special attention from the scientific community as a new carbon material with unique properties. Along with the macrosize diamond, those nanoparticles exhibit an exceptional hardness and sp3-core whereas, the size allows different applications. Among others they can be applied in new composites, lubrication oils, polishing and electronic materials, and drug deliver...
No geral, 4% da carga global de doença é atribuível ao álcool.1 Estudos indicam que os estudantes universitários, em muitos países, têm um elevado risco de consumo excessivo de álcool, com graves riscos para a saúde.
Morphological, particularly textural, discontinuities between horizons increase soil erodibility in Depressão Central, Rio Grande do Sul State (Brazil). Characterization of such discontinuities would help to understand landscape evolution and to model near-surface hydrology. The objective of this research was to explore the relationship between morphological discontinuity and deposition of transported materials...
Introduction Disorders that affect glucose metabolism, namely diabetes mellitus (DM), may favor the development and/or progression of osteoarthritis (OA). Thus far, little is known regarding the ability of chondrocytes to adjust to variations in the extracellular glucose concentration, resulting from hypoglycemia and hyperglycemia episodes, and so, to avoid deleterious effects resulting from deprivation or intr...
Nuclear factor-κB is a key transcription factor activated by pro-inflammatory signals, like interleukin-1β (IL-1), being required for the expression of many inflammatory and catabolic mediators, such as nitric oxide (NO), that play an important role in arthritic diseases. This work aimed at screening and identifying natural inhibitors of IL-induced NF-κB activation and NO production in human articular chondrocy...
Objective: Allogeneic cartilage is used to repair damaged areas of articular cartilage, requiring the presence of living chondrocytes. So far, no preservation method can effectively meet that purpose. Identification of more effective cryoprotective agents (CPAs) can contribute to this goal. The aim of this study was to determine whether the glycosylated hydroquinone, arbutin, alone or in combination with low co...
Nuclear factor-κB is a key transcription factor activated by pro-inflammatory signals, like interleukin-1β (IL-1), being required for the expression of many inflammatory and catabolic mediators, such as nitric oxide (NO), that play an important role in arthritic diseases. This work aimed at screening and identifying natural inhibitors of IL-induced NF-κB activation and NO production in human articular chondrocy...
JUSTIFICATIVA E OBJETIVOS: O desmame da ventilação mecânica é um importante processo e rotineiro nas unidades de terapia intensiva (UTI). O objetivo deste estudo foi identificar, caracterizar e demonstrar as práticas utilizadas por fisioterapeutas respiratórios na obtenção dos parâmetros de desmame, bem como a sua execução em UTI. MÉTODO: Foram incluídos somente fisioterapeutas atuantes em UTI no DF, no ano de ...
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