Document details

Impaired glucose transporter-1 degradation and increased glucose transport and ...

Author(s): Rosa, Susana C. cv logo 1 ; Gonçalves, Juliana cv logo 2 ; Judas, Fernando cv logo 3 ; Mobasheri, Ali cv logo 4 ; Lopes, Celeste cv logo 5 ; Mendes, Alexandrina F. cv logo 6

Date: 2009

Persistent ID: http://hdl.handle.net/10316/11789

Origin: Estudo Geral - Universidade de Coimbra

Subject(s): diabetes mellitus; osteoartrite


Description
Introduction Disorders that affect glucose metabolism, namely diabetes mellitus (DM), may favor the development and/or progression of osteoarthritis (OA). Thus far, little is known regarding the ability of chondrocytes to adjust to variations in the extracellular glucose concentration, resulting from hypoglycemia and hyperglycemia episodes, and so, to avoid deleterious effects resulting from deprivation or intracellular accumulation of glucose. The aim of this study was to compare the ability of normal and OA chondrocytes to regulate their glucose transport capacity in conditions of insufficient or excessive extracellular glucose and to identify the mechanisms involved and eventual deleterious consequences, namely the production of reactive oxygen species (ROS). 1Center for Neurosciences and Cell Biology, and Faculty of Pharmacy, University of Coimbra, 3004-517 Coimbra, Portugal 2Orthopaedics Department, University Hospital of Coimbra, Avenida Bissaya Barreto, Bloco de Celas, 3000-075 Coimbra, Portugal 3Division of Veterinary Medicine, School of Veterinary Science and Medicine, Sutton Bonington Campus, University of Nottingham, Sutton Bonington LE12 5RD, UK
Document Type Article
Language English
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