Sustained drug released from contact lens

• Autor(es): Ferreira, J. A. ; Oliveira, P. de ; Silva, P. M. da ; Carreira, A. ; Gil, H. ; Murta, J. N.
• Data: 2009
• Identificador Persistente: http://hdl.handle.net/10316/11167
• Origem: Estudo Geral - Universidade de Coimbra
• Assunto(s): Ophthalmic drug delivery; Contact lenses; p-(HEMA/MAA); Reaction-diffusion equation; Qualitative behaviour; Numerical simulation; Experimental results
• Tipo de Documento: Preprint
• Idioma: Inglês

Descrição

This paper focuses on ophthalmic drug release from a loaded copolymer: the drug is dispersed in the polymeric matrix and entrapped in particles. The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. Experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days. Project PTDC/MAT/74548/2006