Author(s):
Burke, Anthony 
; Marques, Carolina
Date: 2013
Persistent ID: http://hdl.handle.net/10174/9971
Origin: Repositório Científico da Universidade de Évora
Subject(s): Síntese; Catálise
Document details
Ethyl 2,2-bis(4-methylphenylsulfonamido)acetate to aromatic alpha-amino acids: ...
Description
This paper reports the development of a novel methodology for the catalytic synthesis of aromatic alpha-amino acids, which involves the addition of aryl-organoboron reagents to alpha,alpha-ditosylamino esters derived from ethyl glyoxylate, using transition metal catalysts, like Rh and Pd. A library of alpha-amino esters (12 with Pd and 8 with Rh), was synthesized with moderate to excellent yields. A highest enantioselectivity of 30% ee was obtained using Hayashi's ligand. This method was applied to the synthesis of phenylglycine.
This paper reports the development of a novel methodology for the catalytic synthesis of aromatic alpha-amino acids, which involves the addition of aryl-organoboron reagents to alpha,alpha-ditosylamino esters derived from ethyl glyoxylate, using transition metal catalysts, like Rh and Pd. A library of alpha-amino esters (12 with Pd and 8 with Rh), was synthesized with moderate to excellent yields. A highest enantioselectivity of 30% ee was obtained using Hayashi's ligand. This method was applied to the synthesis of phenylglycine.
Document Type
Article
Language Portuguese
Editor(s) Ghosez, Leon
Language Portuguese
Editor(s) Ghosez, Leon
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